Percutaneous Absorption: Controlled Drug Delivery For Topical or Systemic Therapy
نویسندگان
چکیده
منابع مشابه
Gelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...
متن کاملGelatin Microspheres for the Controlled Release of All-trans-Retinoic Acid Topical Formulation and Drug Delivery Evaluation
A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin. The particle size range of microspheres was between 90-150 m m. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed H...
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BACKGROUND Reactive oxygen species generated by ultraviolet light result in photocarcinogenic and photoaging changes in the skin. Antioxidants protect skin from these insults. OBJECTIVE This study defines formulation characteristics for delivering L-ascorbic acid into the skin to supplement the skin's natural antioxidant reservoir. METHODS L-ascorbic acid or its derivatives were applied to ...
متن کاملIntegro-differential models for percutaneous drug absorption
In this paper we propose a new mathematical models for percutaneous absorption of a drug based on integro-differential equations. We study the qualitative properties of the solution of the models and its numerical approximation. Simulation of proposed numerical methods is carried out.
متن کاملSystemic absorption of topical gentamicin sinus irrigation.
OBJECTIVE Evidence surrounding systemic absorption of gentamicin during intraoperative irrigation of the paranasal sinuses is lacking. The objectives of this study were to determine (1) if topical gentamicin is absorbed from the paranasal sinuses, (2) if hearing loss occurs following topical administration of gentamicin, and (3) if gentamicin placed within the sinuses travels retrograde (agains...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1976
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12544519